Operational experience with a powered-lift STOL aircraft

The experience gained in over four years of STOL operations with the augmentor wing research aircraft and the background of operation of other STOL powered-lift aircraft indicate that the use and percent of lift achieved by powered lift have significant effects on the operational characteristics of STOL aircraft and, therefore, on the performance that can be achieved. A brief description of the augmentor wing including the means by which it achieves its powered lift is presented. Specific problem areas relating to the control of longitudinal flight path are discussed as well as the consequences these might have on the design and operation of this class of aircraft. Particular emphasis is given to the approach and landing phase of flight where the consequences of the powered lift are most pronounced, and the resultant characteristics most different from those of conventional aircraft

A Flight Investigation of the STOL Characteristics of an Augmented Jet Flap STOL Research Aircraft

The flight test program objectives are: (1) To determine the in-flight aerodynamic, performance, and handling qualities of a jet STOL aircraft incorporating the augmented jet flap concept; (2) to compare the results obtained in flight with characteristics predicted from wind tunnel and simulator test results; (3) to contribute to the development of criteria for design and operation of jet STOL transport aircraft; and (4) to provide a jet STOL transport aircraft for STOL systems research and development. Results obtained during the first 8 months of proof-of-concept flight testing of the aircraft in STOL configurations are reported. Included are a brief description of the aircraft, fan-jet engines, and systems; a discussion of the aerodynamic, stability and control, and STOL performance; and pilot opinion of the handling qualities and operational characteristics

Flight investigation of methods for implementing noise-abatement landing approaches

Flight tests and simulation of steep noise reducing landing approaches with jet transpor

Uncorking \u3cem\u3eGranholm\u3c/em\u3e: Extending the Nondiscrimination Principle to all Interstate Commerce in Wine

In a landmark 2005 decision, Granholm v. Heald, the U.S. Supreme Court ruled that states could not constitutionally discriminate in interstate commerce by permitting in-state wineries to ship directly to customers while prohibiting the same for out-of-state wineries. States previously had argued, with some success historically, that the Twenty-first Amendment authorized them to regulate liquor as they pleased—-without Commerce Clause interference. Granholm seemed to clearly establish, once and for all, that “the Twenty-first Amendment does not supersede other provisions of the Constitution.” Several recent federal courts of appeals, however, have refused to heed this clear message when confronted with challenges to laws discriminating against out-of-state wine retailers. This Note argues that a simple Commerce Clause analysis should apply to discrimination against all out-of-state business interests, regardless of their status with respect to the traditional three-tier regulatory system

Recursive relations for a quiver gauge theory

We study the recursive relations for a quiver gauge theory with the gauge group $SU(N_1)\times SU(N_2)$ with bifundamental fermions transforming as $(N_1,\bar{N_2})$. We work out the recursive relation for the amplitudes involving a pair of quark and antiquark and gluons of each gauge group. We realize directly in the recursive relations the invariance under the order preserving permutations of the gluons of the first and the second gauge group. We check the proposed relations for MHV, 6-point and 7-point amplitudes and find the agreements with the known results and the known relations with the single gauge group amplitudes. The proposed recursive relation is much more efficient in calculating the amplitudes than using the known relations with the amplitudes of the single gauge group.Comment: 33 pages and 2 figures, minor correction

Automation for interactive proof: First prototype

AbstractInteractive theorem provers require too much effort from their users. We have been developing a system in which Isabelle users obtain automatic support from automatic theorem provers (ATPs) such as Vampire and SPASS. An ATP is invoked at suitable points in the interactive session, and any proof found is given to the user in a window displaying an Isar proof script. There are numerous differences between Isabelle (polymorphic higher-order logic with type classes, natural deduction rule format) and classical ATPs (first-order, untyped, and clause form). Many of these differences have been bridged, and a working prototype that uses background processes already provides much of the desired functionality

Zimp7 and Zimp10, two novel PIAS-like proteins, function as androgen receptor coregulators

The androgen receptor (AR) plays a critical role in male sexual development and in normal and malignant prostate cell growth and survival. It has been shown that AR transcriptional activation is regulated through interactions with a variety of transcriptional co-regulators. The Protein Inhibitors of Activated STATs (PIAS) are transcriptional co-regulators, and have been shown to modulate AR-mediated transcription. In this brief, we summarize our recent studies on two novel PIAS-like proteins, Zimp7 and Zimp10. Particularly, we address the functional interactions between the AR and these two proteins, and potential mechanisms by which they regulate AR mediated transcription. In addition, we explore potential roles of Zimp10 in transcriptional regulation in vivo using a recent Zimp10 knockout mouse model. Taken together, our findings thus far suggest that Zimp7 and Zimp10 are functionally non-redundant and share unique characteristics that have not been described for the PIAS family. Further investigation into the functional roles of these two PIAS-like proteins may help to better understand prostate cancer progression, and yield possible new targets for therapeutic intervention

Exclusive breastfeeding duration and infant infection

BACKGROUND/OBJECTIVES: We estimated the risk of infection associated with the duration of exclusive breastfeeding (EBF). SUBJECT/METHODS: We analysed the data on 15 809 term, singleton infants from the UK Millennium Cohort Study. Infants were grouped according to months of EBF: never, <2, 2-4, 4-6 and 6 (the latter being World Health Organisation (WHO) policy since 2001: 'post-2001 WHO policy'). Among those EBF for 4-6 months, we separated those who started solids, but not formula, before 6 months, and were still breastfeeding at 6 months (that is, WHO policy before 2001: 'pre-2001 WHO policy'), from other patterns. Outcomes were infection in infancy (chest, diarrhoeal and ear). RESULTS: EBF was not associated with the ear infection, but was associated with chest infection and diarrhoea. EBF for <4 months was associated with a significantly increased risk of chest infection (adjusted risk ratios (RR) 1.24-1.28) and diarrhoea (adjusted RRs 1.42-1.66) compared with the pre-2001 WHO policy. There was an excess risk of the chest infection (adjusted RR 1.19, 95% confidence interval (CI): 0.97-1.46) and diarrhoea (adjusted RR 1.66, 95% CI: 1.11, 2.47) among infants EBF for 4-6 months, but who stopped breastfeeding by 6 months, compared with the pre-2001 WHO policy. There was no significant difference in the risk of chest infection or diarrhoea in those fed according to the pre-2001 versus post-2001 WHO policy. CONCLUSIONS: There is an increased risk of infection in infants EBF for <4 months or EBF for 4-6 months who stop breastfeeding by 6 months. These results support current guidelines of EBF for either 4-6 or 6 months, with continued breastfeeding thereafter.European Journal of Clinical Nutrition advance online publication, 27 July 2016; doi:10.1038/ejcn.2016.135

Learned changes in outcome associability

When a cue reliably predicts an outcome, the associability of that cue will change. Associative theories of learning propose this change will persist even when the same cue is paired with a different outcome. These theories, however, do not extend the same privilege to an outcome; an outcome’s learning history is deemed to have no bearing on subsequent new learning involving that outcome. Two experiments were conducted which sought to investigate this assumption inherent in these theories using a serial letter-prediction task. In both experiments participants were exposed, in Stage 1, to a predictable outcome (‘X’) and an unpredictable outcome (‘Z’). In Stage 2 participants were exposed to the same outcomes preceded by novel cues which were equally predictive of both outcomes. Both experiments revealed that participants’ learning toward the previously predictable outcome was more rapid in Stage 2 than the previously unpredicted outcome. The implications of these results for theories of associative learning are discussed